HCG18
Chr 6HLA complex group 18
Also known as: HCG17
Clinical Summary— HCG18
📋
ClinVar Variants
2 Pathogenic / Likely Pathogenic of 2 total submissions
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
2 submitted variants in ClinVar
Classification Summary
Pathogenic2
2
Pathogenic
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 2 |
Likely Pathogenic | — | — | — | — | 0 |
VUS | — | — | — | — | 0 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 0 |
| Total | — | 2 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →HCG18 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Upregulated lncRNA HCG18 in Patients with Non-Alcoholic Fatty Liver Disease and Its Regulatory Effect on Insulin Resistance
Xia Y et al.·Diabetes Metab Syndr Obes
2021Cohort
Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway
Ni Q et al.·Cancer Gene Ther
2023
Identification of HCG18 and MCM3AP-AS1 That Associate With Bone Metastasis, Poor Prognosis and Increased Abundance of M2 Macrophage Infiltration in Prostate Cancer
Chen Y et al.·Technol Cancer Res Treat
2021
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
Targeting HCG18 counteracts ferroptosis resistance via blocking the miR-30a-5p/RRM2/GSS pathway in hepatocellular carcinoma.
Zhan T et al.·Int J Biol Sci
2025
LncRNA HCG18 contributes to nasopharyngeal carcinoma development by modulating miR-140/CCND1 and Hedgehog signaling pathway.
Li L et al.·Eur Rev Med Pharmacol Sci
2019
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
HCG18 is a Potential Pathogenic Factor and Diagnostic Biomarker Alzheimer's Disease.
Chen P et al.·Neurochem Res
2026
LncRNA HCG18 regulates the progression of spinal tuberculosis by modulating the hsa-miR-146a-5p/TGF-β1/SMADs pathway.
Li F et al.·J Orthop Surg Res
2025Open Access
HCG18 Promotes Cell Proliferation and Stemness in Cholangiocarcinoma via the miR-194-5p/KRT18/MAPK Signaling.
Tian G et al.·Biochem Genet
2025
LncRNA HCG18 affects aortic dissection through the miR-103a-3p/HMGA2 axis by modulating proliferation and apoptosis of vascular smoothing muscle cells.
Yang Z et al.·Clinics (Sao Paulo)
2024Open Access
Top 5 resultsSearch Europe PMC ↗
External Resources
Links to major genomics databases and tools