HCG11

Chr 6

HLA complex group 11

Also known as: CTA-14H9.3, bK14H9.3

NCBI Gene: 493812ENSG00000228223
3
ClinVar variants
2
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— HCG11
📋
ClinVar Variants
2 Pathogenic / Likely Pathogenic· 1 VUS of 3 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

3 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic2
VUS1
2
Pathogenic
1
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————2
Likely Pathogenic
————0
VUS
————1
Likely Benign
————0
Benign
————0
Total—3

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

HCG11 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
The role and mechanism of HLA complex group 11 in cancer.
Yuan X et al.·Biomed Pharmacother
2021Review
Clinical Significance and Biological Role of LncRNA HCG11 in Diabetic Retinopathy.
Ling J et al.·Tohoku J Exp Med
2026
Deregulated Long Non-Coding RNA HCG11 in Cerebral Atherosclerosis Serves as a Biomarker to Predict the Risk of Cerebrovascular Events.
Du J et al.·Clin Appl Thromb Hemost
2023
Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis.
Su Z et al.·Mol Med Rep
2021
LncRNA HCG11 enhances the chemosensitivity of non-small cell lung cancer cells to Gemcitabine via miR-17-5p/p21 axis.
Xu Y et al.·Expert Rev Anticancer Ther
2024
Modulation of IGF2BP1 by long non-coding RNA HCG11 suppresses apoptosis of hepatocellular carcinoma cells via MAPK signaling transduction.
Xu Y et al.·Int J Oncol
2017
Long non-coding RNA HCG11 sponging miR-522-3p inhibits the tumorigenesis of non-small cell lung cancer by upregulating SOCS5.
Fan G et al.·Thorac Cancer
2020
Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis.
Datta I et al.·J Transl Med
2021
The clinical value of serum long non-coding RNA human leukocyte antigen complex group 11/microRNA-532-3p in the diagnosis and prognosis of patients with acute myocardial infarction undergoing percutaneous coronary intervention.
Cao Y et al.·J Cardiothorac Surg
2024Cohort
Long non-coding RNAs as prognostic markers in human breast cancer.
Liu H et al.·Oncotarget
2016
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools