H4C5
Chr 6ADH4 clustered histone 5
Also known as: H4/j, H4FJ, HIST1H4E, TEBIVANED3, TEVANED3
This gene encodes histone H4, a core component of nucleosomes that wraps and compacts DNA into chromatin and regulates DNA accessibility through post-translational modifications. Mutations cause Tessadori-Bicknell-van Haaften neurodevelopmental syndrome 3, which follows autosomal dominant inheritance. This represents a chromatin remodeling disorder affecting transcription regulation and chromosomal stability during development.
Strong evidence — appropriate for clinical testing
Some data sources returned errors (1)
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
H4C5 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
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Links to major genomics databases and tools