H1-5

Chr 6

H1.5 linker histone, cluster member

Also known as: H1, H1.5, H1B, H1F5, H1s-3, HIST1H1B

NCBI Gene: 3009ENSG00000184357UniProt: P16401

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
5
Active trials
14
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.10
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
1.10LOEUF
pLI 0.575
Z-score 1.50
OE 0.00 (0.00–1.10)
Moderately constrained

Highly tolerant — LoF variants common in population

Missense Constraint?
-3.54Z-score
OE missense 1.90 (1.69–1.98)
232 obs / 122.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.00 (0.00–1.10)
0≤0.351.4
Missense OE?1.90 (1.69–1.98)
0≤0.61.4
Synonymous OE?2.25
0≤1.21.6
LoF obs/exp: 0 / 2.6Missense obs/exp: 232 / 122.0Syn Z: -7.13

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

H1-5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients