H1-2
Chr 6H1.2 linker histone, cluster member
Also known as: H1.2, H1C, H1F2, H1s-1, HIST1H1C
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
H1-2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy
RECRUITINGThe PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock
RECRUITINGExamining the Effects of Theory-based Education on Individuals' Sexual Behavior.
ACTIVE NOT RECRUITINGEffect of Postoperative Telehealth Counseling on Recovery and Self-Care in Geriatric Day Surgery Patients
NOT YET RECRUITINGMIBG Therapy for Patients With MIBG Avid Tumors
ACTIVE NOT RECRUITINGIndividualized Dose of Fibrinogen Following Cardiopulmonary Bypass
NOT YET RECRUITINGPhase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)
ACTIVE NOT RECRUITINGPhysiotherapy in Chronic Neck Pain
ENROLLING BY INVITATIONATA-100 (Formerly GNT0006) Gene Therapy Trial in Patients With LGMDR9
ACTIVE NOT RECRUITINGEfficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy
NOT YET RECRUITINGA Trial Comparing the Efficacy and Safety of Anakinra Versus Intravenous Immunoglobulin (IVIG) Retreatment, in Patients With Kawasaki Disease Who Failed to Respond to Initial Standard IVIG Treatment
RECRUITINGCorticosteroids Before Extubation in Pediatric Intensive Care Unit
RECRUITINGExternal Resources
Links to major genomics databases and tools