H1-1
Chr 6H1.1 linker histone, cluster member
Also known as: H1.1, H1A, H1F1, HIST1, HIST1H1A
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
H1-1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Hot Compress Application in Open Abdominal Surgery
RECRUITINGExamining the Effects of Theory-based Education on Individuals' Sexual Behavior.
ACTIVE NOT RECRUITINGEffect of Postoperative Telehealth Counseling on Recovery and Self-Care in Geriatric Day Surgery Patients
NOT YET RECRUITINGPhysiotherapy in Chronic Neck Pain
ENROLLING BY INVITATIONThe Effect of Proprioceptive Neuromuscular Facilitation on Haemodynamic Responses in a Neurological Intensive Care
NOT YET RECRUITINGEffects of Shotblocker and Manual Pressure on Pain and Satisfaction
NOT YET RECRUITINGEFFECTS OF CİTRUS AND CLOVE OİL AROMATHERAPY İN OLDER ADULTS
NOT YET RECRUITINGThe Effect of Breathing Exercise Applied to Intensive Care Nurses on Fatigue and Perceived Stress
RECRUITINGFirst-in-human Study Aiming to Characterize the Safety, Tolerability, Pharmacokinetic and Preliminary Signs of Activity of ABD-3001 in Refractory or Relapsed AML and High Risk MDS Adult Patients
RECRUITINGPredictors of Motor İmagery Performance in Cerebral Palsy
NOT YET RECRUITINGThe Effect of Laughter Yoga Practice in Hypertension Patients
NOT YET RECRUITINGAre Developmentally At Risky Babies Environmentally Disadvantaged?
NOT YET RECRUITINGExternal Resources
Links to major genomics databases and tools