GUCA2A
Chr 1guanylate cyclase activator 2A
Also known as: GCAP-I, GUCA2, STARA
The protein functions as an endogenous activator of intestinal guanylate cyclase, stimulating the enzyme through the same receptor binding region as heat-stable enterotoxins. Based on available databases, no well-established Mendelian diseases have been definitively linked to GUCA2A mutations in humans. The gene shows moderate tolerance to loss-of-function variants (pLI = 0.29, LOEUF = 1.21), suggesting it may not be essential for normal development.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
GUCA2A · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools