GTF3C4
Chr 9general transcription factor IIIC subunit 4
The protein functions as an essential component of transcription factor TFIIIC complex, enabling RNA polymerase III to transcribe small nuclear and cytoplasmic RNAs including 5S rRNA and tRNA, and also has histone H3K14 acetyltransferase activity. GTF3C4 mutations have not been definitively associated with human disease, though the low LOEUF score (0.444) suggests intolerance to loss-of-function variants. The inheritance pattern and specific pathogenic mechanisms remain to be established through future clinical studies.
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
GTF3C4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools