GSTT2

Chr 22

glutathione S-transferase theta 2 (gene/pseudogene)

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1417752). Has a sulfatase activity (PubMed:1417752)

OMIMResearchGenerating clinical summary…
0
Active trials
4
Pubs (1 yr)
P/LP submissions
P/LP missense
1.61
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.61LOEUF
pLI 0.015
Z-score 0.65
OE 0.67 (0.301.61)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.89Z-score
OE missense 0.63 (0.470.86)
30 obs / 47.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.67 (0.301.61)
00.351.4
Missense OE?0.63 (0.470.86)
00.61.4
Synonymous OE?0.92
01.21.6
LoF obs/exp: 3 / 4.5Missense obs/exp: 30 / 47.3Syn Z: 0.27

ClinVar

No ClinVar data available.

Protein Context — Lollipop Plot

GSTT2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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