GSTP1

Chr 11

glutathione S-transferase pi 1

Also known as: DFN7, FAEES3, GST3, GSTP, GSTP1-1, HEL-S-22, PI

NCBI Gene: 2950ENSG00000084207UniProt: P09211

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

61
ClinVar variants
13
Pathogenic / LP
0.01
pLI score
1
Active trials
Clinical Summary— GSTP1
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.01) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
13 Pathogenic / Likely Pathogenic· 23 VUS of 61 total submissions
💊
Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
0.85LOEUF
pLI 0.014
Z-score 1.93
OE 0.41 (0.21–0.85)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
-0.33Z-score
OE missense 1.09 (0.94–1.26)
129 obs / 118.8 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.41 (0.21–0.85)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.1.09 (0.94–1.26)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.83
0≤1.21.6
LoF obs/exp: 5 / 12.3Missense obs/exp: 129 / 118.8Syn Z: 1.00

ClinVar Variant Classifications

61 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic10
Likely Pathogenic3
VUS23
Likely Benign1
Benign24
10
Pathogenic
3
Likely Pathogenic
23
VUS
1
Likely Benign
24
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
10
0
10
Likely Pathogenic
0
0
3
0
3
VUS
0
18
5
0
23
Likely Benign
0
0
0
1
1
Benign
0
4
18
2
24
Total02236361

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

GSTP1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
GSTP1 inhibits angiotensin II-induced atrial fibrillation by regulating ferroptosis.
Li H et al.·Europace
2025
Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells.
Zhang Y et al.·Redox Biol
2024
Clinical significance and association of GSTP1 hypermethylation with hepatocellular carcinoma: A meta-analysis.
Li Y et al.·J Cancer Res Ther
2018Review
Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment.
Liaño-Pons J et al.·Proc Natl Acad Sci U S A
2025
GSTP1 and GSTO1 Variant Alleles Affect Susceptibility to Helicobacter pylori Infection and Severity of Helicobacter pylori-Associated Clinical Manifestations.
Pantic I et al.·Int J Mol Sci
2025
Genetic polymorphism and cancer risk.
Clapper ML·Curr Oncol Rep
2000Review
Polymorphism and transcriptional regulation of GSTP1 in cancer and other human diseases.
Zeng QR et al.·Int J Biol Macromol
2026Review
Association between GSTP1 Ile105Val polymorphism and oxaliplatin-induced neuropathy: a systematic review and meta-analysis.
Peng Z et al.·Cancer Chemother Pharmacol
2013Meta-analysis
GSTP1 methylation in cancer: a liquid biopsy biomarker?
Gurioli G et al.·Clin Chem Lab Med
2018Review
Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis.
Yu Z et al.·Tumour Biol
2013Meta-analysis
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Inflammatory Bowel Diseases

Markers of Oxidative Stress in Inflammatory Bowel Diseases: Risk Factors and Implications for a Dietetic Approach

ACTIVE NOT RECRUITING
NCT04513015Phase NAUniversità Politecnica delle MarcheStarted 2019-12-15
Antioxidant dietNormal dietetic scheme

External Resources

Links to major genomics databases and tools