GSTCD

Chr 4

glutathione S-transferase C-terminal domain containing

NCBI Gene: 79807ENSG00000138780UniProt: Q8NEC7OMIM: 615912

Predicted to act upstream of or within respiratory system development and response to lipopolysaccharide. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.81
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.81LOEUF
pLI 0.000
Z-score 2.36
OE 0.53 (0.36–0.81)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.34Z-score
OE missense 0.95 (0.86–1.04)
304 obs / 321.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.53 (0.36–0.81)
0≤0.351.4
Missense OE?0.95 (0.86–1.04)
0≤0.61.4
Synonymous OE?1.04
0≤1.21.6
LoF obs/exp: 16 / 30.0Missense obs/exp: 304 / 321.4Syn Z: -0.34

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GSTCD · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients