GSTA5

Chr 6

glutathione S-transferase alpha 5

NCBI Gene: 221357ENSG00000182793UniProt: Q7RTV2

The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]

ResearchGenerating clinical summary…
0
Active trials
6
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.91
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.91LOEUF
pLI 0.000
Z-score -1.26
OE 1.43 (0.93–1.91)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.36Z-score
OE missense 1.36 (1.19–1.55)
158 obs / 116.6 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.43 (0.93–1.91)
0≤0.351.4
Missense OE?1.36 (1.19–1.55)
0≤0.61.4
Synonymous OE?1.20
0≤1.21.6
LoF obs/exp: 14 / 9.8Missense obs/exp: 158 / 116.6Syn Z: -1.00

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GSTA5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients