GRK5

Chr 10

G protein-coupled receptor kinase 5

Also known as: FP2025, GPRK5

NCBI Gene: 2869ENSG00000198873UniProt: P34947

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
54
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.38
LOEUF
GOF
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.38LOEUF
pLI 0.676
Z-score 4.33
OE 0.20 (0.12–0.38)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
2.16Z-score
OE missense 0.68 (0.61–0.76)
245 obs / 360.3 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios?
LoF OE?0.20 (0.12–0.38)
0≤0.351.4
Missense OE?0.68 (0.61–0.76)
0≤0.61.4
Synonymous OE?0.96
0≤1.21.6
LoF obs/exp: 7 / 34.4Missense obs/exp: 245 / 360.3Syn Z: 0.38

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GRK5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients