GRIFIN

Chr 7

galectin-related inter-fiber protein

NCBI Gene: 402635ENSG00000275572UniProt: A4D1Z8

Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Jul 2025]

18
ClinVar variants
13
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— GRIFIN
📋
ClinVar Variants
13 Pathogenic / Likely Pathogenic· 4 VUS of 18 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

18 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic13
VUS4
Likely Benign1
13
Pathogenic
4
VUS
1
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————13
Likely Pathogenic
————0
VUS
————4
Likely Benign
————1
Benign
————0
Total—18

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

GRIFIN · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens.
Barton KA et al.·Biochemistry
2009
Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a functional carbohydrate-binding galectin.
Ahmed H et al.·Biochem Biophys Res Commun
2008Functional
Chicken GRIFIN: A homodimeric member of the galectin network with canonical properties and a unique expression profile.
García Caballero G et al.·Biochimie
2016
Expressed sequence tag analysis of guinea pig (Cavia porcellus) eye tissues for NEIBank.
Simpanya MF et al.·Mol Vis
2008
Transcriptomics Analysis of Lens from Patients with Posterior Subcapsular Congenital Cataract.
Lin X et al.·Genes (Basel)
2021Cohort
Identification and characterization of endogenous galectins expressed in Madin Darby canine kidney cells.
Poland PA et al.·J Biol Chem
2011
Twenty-five years of child and family homelessness: where are we now?
Grant R et al.·Am J Public Health
2013Review
Proportion of subjects with psychotic features in bipolar disorder correlated with treatment response by antipsychotics for acute mania.
Ikeda M et al.·Psychiatry Clin Neurosci
2022
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia.
Ge SQ et al.·Genet Mol Res
2015
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools