GRIA3
Chr XXLRglutamate ionotropic receptor AMPA type subunit 3
Also known as: GLUR-C, GLUR-K3, GLUR3, GLURC, GluA3, MRX94, MRXSW, iGluR3
The protein functions as an AMPA-sensitive glutamate receptor subunit that forms ligand-gated ion channels mediating excitatory neurotransmission in the brain. Mutations cause X-linked syndromic intellectual developmental disorder (Wu type) through an X-linked recessive inheritance pattern. The high constraint scores (pLI 0.999, LOEUF 0.193) indicate that pathogenic variants likely cause disease through loss of function of this essential glutamate receptor subunit.
Definitive — sufficient evidence for diagnostic panels
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Highly missense-constrained (top ~0.1%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
GRIA3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools