GRB10
Chr 7growth factor receptor bound protein 10
Also known as: GRB-IR, Grb-10, IRBP, MEG1, RSS
The GRB10 protein is an adapter protein that negatively regulates insulin and insulin-like growth factor receptor signaling by blocking downstream pathways and promoting receptor degradation. Mutations cause Silver-Russell syndrome, characterized by severe intrauterine and postnatal growth restriction, relative macrocephaly, and feeding difficulties typically apparent from birth. This gene shows parent-of-origin effects with brain-specific paternal expression and is highly intolerant to loss-of-function variants.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
GRB10 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools