GRAMD2B

Chr 5

GRAM domain containing 2B

Also known as: GRAMD3, NS3TP2

NCBI Gene: 65983ENSG00000155324UniProt: Q96HH9OMIM: 620182

Enables identical protein binding activity. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.14
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.14LOEUF
pLI 0.000
Z-score 0.99
OE 0.79 (0.56–1.14)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.04Z-score
OE missense 0.81 (0.71–0.91)
183 obs / 227.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.79 (0.56–1.14)
0≤0.351.4
Missense OE?0.81 (0.71–0.91)
0≤0.61.4
Synonymous OE?0.96
0≤1.21.6
LoF obs/exp: 21 / 26.5Missense obs/exp: 183 / 227.1Syn Z: 0.28

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GRAMD2B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients