GPRIN3

Chr 4

GPRIN family member 3

Also known as: GRIN3

NCBI Gene: 285513 ENSG00000185477 UniProt: Q6ZVF9 OMIM: 611241

The GPRIN3 protein is predicted to be involved in neuron projection development and may play a role in neurite outgrowth. Mutations in this gene have been associated with neurodevelopmental disorders, though the specific clinical phenotypes and inheritance patterns are not well-established from the available data. The gene appears to be tolerant of loss-of-function variants based on constraint metrics.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to be involved in neuron projection development. Predicted to act upstream of or within several processes, including excitatory chemical synaptic transmission; neuronal action potential; and vitamin D receptor signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.47

LOEUF

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Mechanism