GPRIN3
Chr 4GPRIN family member 3
Also known as: GRIN3
The GPRIN3 protein is predicted to be involved in neuron projection development and may play a role in neurite outgrowth. Mutations in this gene have been associated with neurodevelopmental disorders, though the specific clinical phenotypes and inheritance patterns are not well-established from the available data. The gene appears to be tolerant of loss-of-function variants based on constraint metrics.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
168 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 25 | 0 | 25 |
Likely Pathogenic | 0 | 0 | 2 | 0 | 2 |
VUS | 0 | 125 | 2 | 0 | 127 |
Likely Benign | 0 | 10 | 1 | 1 | 12 |
Benign | 0 | 1 | 0 | 0 | 1 |
| Total | 0 | 136 | 30 | 1 | 167 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
GPRIN3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools