GPRIN2

Chr 10

G protein regulated inducer of neurite outgrowth 2

Also known as: GRIN2, KIAA0514

NCBI Gene: 9721ENSG00000204175UniProt: O60269OMIM: 611240

Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.49
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.49LOEUF
pLI 0.000
Z-score 0.42
OE 0.86 (0.52–1.49)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.56Z-score
OE missense 1.10 (1.00–1.22)
256 obs / 231.9 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.86 (0.52–1.49)
0≤0.351.4
Missense OE?1.10 (1.00–1.22)
0≤0.61.4
Synonymous OE?1.13
0≤1.21.6
LoF obs/exp: 9 / 10.5Missense obs/exp: 256 / 231.9Syn Z: -1.05

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GPRIN2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients