GPR87

Chr 3

G protein-coupled receptor 87

Also known as: FKSG78, GPR95, KPG_002

NCBI Gene: 53836 ENSG00000138271 UniProt: Q9BY21 OMIM: 606379

This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]

OMIM Research

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

—

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

gnomad: TimeoutError: The operation was aborted due to timeout

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in GPR87?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 140

467 rare PASS variants

Rare truncating (LoF)

1 in 440

85 rare PASS variants

Rare synonymous (reference)

1 in 360

181 rare PASS variants

Rare missense and truncating variants are carried at similar rates in GPR87; this gene does not show strong loss-of-function constraint by this measure. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 200	1 in 420
South Asian	~43k	1 in 120	1 in 2,000
Remaining (unassigned)	~30k	1 in 95	1 in 490
European (Finnish)	~27k	1 in 630	≈ 1 in 6,700
Admixed American	~22k	1 in 120	1 in 3,200
African / African American	~21k	1 in 160	1 in 860
East Asian	~20k	1 in 120	1 in 2,200
Ashkenazi Jewish	~13k	1 in 410	none seen
Middle Eastern	~2,884	1 in 150	≈ 1 in 1,400

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 1 of 2 coding exons well covered in gnomAD exomes; exon 2 marginal. Genomes: all 2.? see exons ↓