GPR84

Chr 12

G protein-coupled receptor 84

Also known as: EX33, GPCR4

NCBI Gene: 53831ENSG00000139572UniProt: Q9NQS5

Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
52
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.58
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.58LOEUF
pLI 0.000
Z-score -0.02
OE 1.01 (0.65–1.58)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.40Z-score
OE missense 0.92 (0.83–1.04)
211 obs / 228.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.01 (0.65–1.58)
0≤0.351.4
Missense OE?0.92 (0.83–1.04)
0≤0.61.4
Synonymous OE?0.88
0≤1.21.6
LoF obs/exp: 13 / 12.9Missense obs/exp: 211 / 228.2Syn Z: 0.93

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GPR84 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients