GPR82

Chr X

G protein-coupled receptor 82

NCBI Gene: 27197 ENSG00000171657 UniProt: Q96P67

GPR82 encodes an orphan G protein-coupled receptor with seven transmembrane domains that transduces extracellular signals through heterotrimeric G proteins, though its specific ligand and function remain unknown. Currently, no established human diseases have been definitively associated with GPR82 mutations. The gene shows tolerance to loss-of-function variants (pLI = 0.14, LOEUF = 1.08), suggesting it may not be essential for normal development.

ResearchSummary from RefSeq, UniProt

The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.08

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

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