GPR75

Chr 2

G protein-coupled receptor 75

Also known as: GPRchr2, WI31133

NCBI Gene: 10936ENSG00000119737UniProt: O95800

GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]

ResearchGenerating clinical summary…
0
Active trials
32
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.23
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.23LOEUF
pLI 0.000
Z-score 0.97
OE 0.71 (0.42–1.23)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.04Z-score
OE missense 1.01 (0.91–1.11)
292 obs / 290.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.71 (0.42–1.23)
0≤0.351.4
Missense OE?1.01 (0.91–1.11)
0≤0.61.4
Synonymous OE?1.19
0≤1.21.6
LoF obs/exp: 9 / 12.7Missense obs/exp: 292 / 290.3Syn Z: -1.62

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GPR75 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients