GPR55

Chr 2

G protein-coupled receptor 55

ENSG00000135898 UniProt: Q9Y2T6 OMIM: 604107

GPR55 encodes a G-protein coupled receptor that binds lysophospholipid ligands and activates multiple intracellular signaling pathways, including calcium release and RHOA-mediated cytoskeletal changes. The gene shows very low constraint against loss-of-function variants (pLI ~0, LOEUF 1.7), and no established Mendelian diseases have been definitively linked to GPR55 mutations in the pediatric population. While the receptor may influence lipid metabolism and cellular morphology, its role in human genetic disease remains unclear.

OMIM ResearchSummary from RefSeq, UniProt

G protein-coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935)

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.71

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)