GPR37

Chr 7

G protein-coupled receptor 37

Also known as: EDNRBL, PAELR, hET(B)R-LP

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

OMIMResearchGenerating clinical summary…
0
Active trials
43
Pubs (1 yr)
P/LP submissions
P/LP missense
0.79
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
0.79LOEUF
pLI 0.000
Z-score 2.26
OE 0.45 (0.270.79)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.84Z-score
OE missense 0.88 (0.800.96)
316 obs / 360.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.45 (0.270.79)
00.351.4
Missense OE?0.88 (0.800.96)
00.61.4
Synonymous OE?0.91
01.21.6
LoF obs/exp: 9 / 19.9Missense obs/exp: 316 / 360.9Syn Z: 0.91

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

GPR37 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →