GPR171

Chr 3

G protein-coupled receptor 171

Also known as: H963

NCBI Gene: 29909ENSG00000174946UniProt: O14626OMIM: 618925

Predicted to enable G protein-coupled purinergic nucleotide receptor activity; neuropeptide binding activity; and neuropeptide receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; regulation of feeding behavior; and regulation of sensory perception of pain. Predicted to act upstream of or within negative regulation of myeloid cell differentiation. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
14
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.29
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.29LOEUF
pLI 0.000
Z-score 0.91
OE 0.69 (0.39–1.29)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.20Z-score
OE missense 0.74 (0.64–0.86)
127 obs / 171.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.69 (0.39–1.29)
0≤0.351.4
Missense OE?0.74 (0.64–0.86)
0≤0.61.4
Synonymous OE?1.06
0≤1.21.6
LoF obs/exp: 7 / 10.1Missense obs/exp: 127 / 171.1Syn Z: -0.37

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GPR171 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients