GPR161

Chr 1ADARSomatic

G protein-coupled receptor 161

Also known as: RE2

NCBI Gene: 23432ENSG00000143147UniProt: Q8N6U8OMIM: 612250

The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]

GeneReviewsOMIMResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

{Medulloblastoma predisposition syndrome}MIM #155255
ADARSomatic
Hepatorenocardiac degenerative fibrosisMIM #619902
AR
Medulloblastoma, somaticMIM #155255
{Medulloblastoma predisposition syndrome}MIM #155255
ADARSomatic
Medulloblastoma, somaticMIM #155255
{Medulloblastoma}MIM #155255
ADARSomatic
{Medulloblastoma}MIM #155255
ADARSomatic
{Medulloblastoma}MIM #155255
ADARSomatic

Clinical highlights

Gene-disease validity (ClinGen)
GPR161-related medulloblastoma predisposition · ADStrongappropriate for clinical testing
0
Active trials
20
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.79
LOEUF
Multiple*
Mechanism· predicted
📖
GeneReview available — GPR161
Authoritative clinical overview · Recommended first read
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.79LOEUF
pLI 0.000
Z-score 2.28
OE 0.45 (0.27–0.79)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.51Z-score
OE missense 0.77 (0.69–0.85)
254 obs / 331.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.45 (0.27–0.79)
0≤0.351.4
Missense OE?0.77 (0.69–0.85)
0≤0.61.4
Synonymous OE?1.17
0≤1.21.6
LoF obs/exp: 9 / 20.0Missense obs/exp: 254 / 331.6Syn Z: -1.54

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GPR161 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients