GPR160

Chr 3

G protein-coupled receptor 160

Also known as: GPCR1, GPCR150

NCBI Gene: 26996 ENSG00000173890 UniProt: Q9UJ42

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of signaling receptor complex. [provided by Alliance of Genome Resources, Jun 2026]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.26

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.26LOEUF

pLI 0.001

Z-score 1.02

OE 0.64 (0.35–1.26)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

0.21Z-score

OE missense 0.95 (0.83–1.09)

154 obs / 161.5 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.64 (0.35–1.26)

0≤0.351.4

Missense OE?0.95 (0.83–1.09)

0≤0.61.4

Synonymous OE?0.89

0≤1.21.6

LoF obs/exp: 6 / 9.4Missense obs/exp: 154 / 161.5Syn Z: 0.63

Background carrier burden — how many people carry a rare variant somewhere in GPR160?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 110

368 rare PASS variants

Rare truncating (LoF)

1 in 700

124 rare PASS variants

Rare synonymous (reference)

1 in 790

142 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for GPR160. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 290	1 in 980
South Asian	~43k	1 in 130	1 in 810
Remaining (unassigned)	~30k	1 in 140	1 in 860
European (Finnish)	~27k	1 in 450	1 in 3,800
Admixed American	~22k	1 in 130	1 in 530
African / African American	~21k	1 in 200	1 in 1,100
East Asian	~20k	1 in 180	1 in 1,100
Ashkenazi Jewish	~13k	1 in 1,100	≈ 1 in 6,500
Middle Eastern	~2,883	1 in 240	1 in 260

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 0 of 1 coding exons well covered in gnomAD exomes; exon 4 marginal. Genomes: all 1.? see exons ↓