GPR15LG

Chr 10

G protein-coupled receptor 15 ligand

ENSG00000188373UniProt: Q6UWK7OMIM: 617775

Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G protein-coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May regulate keratinocyte proliferation (PubMed:29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588)

OMIMResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.49
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

ncbi: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.49LOEUF
pLI 0.212
Z-score 1.05
OE 0.34 (0.12–1.49)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.49Z-score
OE missense 1.21 (0.97–1.52)
53 obs / 43.9 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.34 (0.12–1.49)
0≤0.351.4
Missense OE?1.21 (0.97–1.52)
0≤0.61.4
Synonymous OE?0.78
0≤1.21.6
LoF obs/exp: 1 / 2.9Missense obs/exp: 53 / 43.9Syn Z: 0.72

ClinVar

No ClinVar data available.

Protein Context — Lollipop Plot

GPR15LG · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients