GPR158

Chr 10

G protein-coupled receptor 158

Also known as: mGlyR

NCBI Gene: 57512 ENSG00000151025 UniProt: Q5T848

GPR158 encodes a metabotropic glycine receptor that controls synapse formation and function in the brain by regulating G protein signaling and cAMP levels, particularly affecting neuronal excitability in the prefrontal cortex and hippocampus. Mutations cause autosomal recessive neurodevelopmental disorders characterized by intellectual disability, developmental delay, and behavioral abnormalities with childhood onset. This gene is highly constrained against loss-of-function variants (LOEUF 0.467), indicating that biallelic mutations likely cause severe phenotypes.

ResearchSummary from RefSeq, UniProt

Enables G protein-coupled glycine receptor activity and enzyme activator activity. Involved in G protein-coupled receptor signaling pathway; protein localization to plasma membrane; and regulation of G protein-coupled receptor signaling pathway. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.47

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

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