GPR152

Chr 11

G protein-coupled receptor 152

Also known as: PGR5

NCBI Gene: 390212 ENSG00000175514 UniProt: Q8TDT2

GPR152 encodes an orphan G protein-coupled receptor that enables protein binding and is predicted to participate in G protein-coupled receptor signaling pathways at the plasma membrane. The gene shows low constraint against loss-of-function variants (pLI = 0.0004, LOEUF = 1.44), suggesting tolerance to inactivating mutations. No established Mendelian diseases have been associated with GPR152 mutations.

ResearchSummary from RefSeq, UniProt

Enables identical protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

—

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 400

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in GPR152?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 82

579 rare PASS variants

Rare truncating (LoF)

1 in 530

73 rare PASS variants

Rare synonymous (reference)

1 in 140

294 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for GPR152. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 87	1 in 660
South Asian	~43k	1 in 100	1 in 400
Remaining (unassigned)	~30k	1 in 62	1 in 590
European (Finnish)	~27k	1 in 230	1 in 1,200
Admixed American	~22k	1 in 60	1 in 1,200
African / African American	~21k	1 in 58	1 in 1,500
East Asian	~20k	1 in 110	1 in 2,800
Ashkenazi Jewish	~13k	1 in 160	1 in 590
Middle Eastern	~2,884	1 in 66	≈ 1 in 720

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 1 coding exons well covered in gnomAD exomes and genomes.? see exons ↓