GPR12
Chr 13G protein-coupled receptor 12
Also known as: GPCR12, GPCR21, PPP1R84
GPR12 encodes a brain-specific G protein-coupled receptor that regulates neurite outgrowth and lipid/carbohydrate metabolism through constitutive G(s)-mediated signaling and cyclic AMP production. The gene has moderate constraint against loss-of-function variants (LOEUF 0.708), but no definitive human disease associations have been established in the provided data. Clinical significance of GPR12 variants in pediatric neurological disorders remains to be determined.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
This gene has evidence for multiple mechanisms of pathogenicity (gain-of-function and dominant-negative). Both the Badonyi & Marsh prediction and the broader genomic evidence point to gain-of-function as the predominant mechanism. Different variants in this gene may act through different mechanisms — interpret in context of the specific variant.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
70 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 30 | 0 | 30 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 0 | 31 | 3 | 0 | 34 |
Likely Benign | 0 | 0 | 0 | 0 | 0 |
Benign | 0 | 0 | 3 | 1 | 4 |
| Total | 0 | 31 | 37 | 1 | 69 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
GPR12 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools