GPR107
Chr 9G protein-coupled receptor 107
Also known as: GCDRP, LUSTR1, bA138E2.2
The GPR107 protein functions as a receptor for neuronostatin and is involved in glucose homeostasis by inducing glucagon release in response to low glucose levels, while also participating in clathrin-dependent endocytosis. Mutations cause an autosomal dominant neurodevelopmental disorder through a dominant-negative mechanism. The gene shows intolerance to loss-of-function variants (LOEUF 0.42), consistent with the dominant-negative pathogenic mechanism.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
GPR107 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools