GPC1

Chr 2

glypican 1

Also known as: glypican

NCBI Gene: 2817ENSG00000063660UniProt: P35052

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
6
Active trials
45
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.62
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.62LOEUF
pLI 0.016
Z-score 2.87
OE 0.33 (0.19–0.62)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.33Z-score
OE missense 0.95 (0.87–1.04)
346 obs / 363.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.33 (0.19–0.62)
0≤0.351.4
Missense OE?0.95 (0.87–1.04)
0≤0.61.4
Synonymous OE?1.06
0≤1.21.6
LoF obs/exp: 7 / 21.3Missense obs/exp: 346 / 363.9Syn Z: -0.65

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GPC1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Liver CancerRhabdomyosarcomaMalignant Rhabdoid Tumor

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

RECRUITING
NCT04715191Phase PHASE1Baylor College of MedicineStarted 2024-05-24
CARE T cells
Solid Tumor (Excluding CNS)Hepatocellular CarcinomaLiver Cell Carcinoma

Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors

NOT YET RECRUITING
NCT07224568Phase PHASE1Seattle Children's HospitalStarted 2026-04-01
SC-CAR.GPC3xIL15.21 CAR T cells
Liver Cancer

Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Patients With Pediatric Solid Tumors (GAP)

ACTIVE NOT RECRUITING
NCT02932956Phase PHASE1Baylor College of MedicineStarted 2018-12-17
GAP T cellsCytoxanFludara
Liver Cell CarcinomaSolid TumorWilms Tumor

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors

ACTIVE NOT RECRUITING
NCT05103631Phase PHASE1Baylor College of MedicineStarted 2021-06-17
CATCH T cells
Liver CancerRhabdomyosarcomaMalignant Rhabdoid Tumor

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

ACTIVE NOT RECRUITING
NCT04377932Phase PHASE1Baylor College of MedicineStarted 2021-08-08
AGAR T cells
Solid Tumor (Excluding CNS)Liver Cell CarcinomaMalignant Rhabdoid Tumor

Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells

RECRUITING
NCT07148050Phase PHASE1Seattle Children's HospitalStarted 2025-12-22
SC-CAR.GPC3xIL15.21 CAR T cells

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients