GP2
Chr 16glycoprotein 2
Also known as: ZAP75
GP2 encodes a GPI-anchored membrane protein that functions as an intestinal M-cell receptor for type I-piliated bacteria, binding pathogens like E. coli and S. typhimurium to facilitate mucosal immune responses. Mutations cause autosomal recessive early-onset inflammatory bowel disease, typically presenting in infancy or early childhood. The gene shows very low constraint against loss-of-function variants (high LOEUF score), consistent with its recessive inheritance pattern.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
GP2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension
RECRUITINGExploration of the Cellular and Molecular Mechanisms in Patients Receiving Biotherapies Targeting the IL-23/IL-17 Axis in Cutaneous Psoriasis
RECRUITINGExternal Resources
Links to major genomics databases and tools