GNG4
Chr 1G protein subunit gamma 4
Also known as: HG3C
Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
📖
Open GeneReview ↗GeneReview available — GNG4
Authoritative clinical overview · Recommended first read
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.71LOEUF
pLI 0.156
Z-score 0.72
OE 0.47 (0.16–1.71)
Highly tolerant — LoF variants common in population
Missense Constraint?
0.68Z-score
OE missense 0.72 (0.54–0.96)
32 obs / 44.7 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.47 (0.16–1.71)
0≤0.351.4
Missense OE?0.72 (0.54–0.96)
0≤0.61.4
Synonymous OE?0.59
0≤1.21.6
LoF obs/exp: 1 / 2.1Missense obs/exp: 32 / 44.7Syn Z: 1.26
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
GNG4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
📖
Open GeneReview ↗GeneReview available — GNG4
Authoritative clinical overview · NCBI Bookshelf · Recommended first read
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools