GNA13
Chr 17G protein subunit alpha 13
Also known as: G13, HG1N
Enables G protein activity. Involved in Rho-activating G protein-coupled receptor signaling pathway. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Clinical Summary— GNA13
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Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.87) — some intolerance to loss-of-function variants.
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ClinVar Variants
11 Pathogenic / Likely Pathogenic· 29 VUS of 42 total submissions
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
0.41LOEUF
pLI 0.867
Z-score 3.16
OE 0.13 (0.05–0.41)
More LoF-intolerant than ~75% of genes
Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
2.71Z-score
OE missense 0.49 (0.42–0.57)
109 obs / 222.7 exp
Moderately missense-constrained (top ~2.5%)
Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.13 (0.05–0.41)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.49 (0.42–0.57)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.86
0≤1.21.6
LoF obs/exp: 2 / 15.4Missense obs/exp: 109 / 222.7Syn Z: 0.99
ClinVar Variant Classifications
42 submitted variants in ClinVar
Classification Summary
Pathogenic11
VUS29
Benign2
11
Pathogenic
29
VUS
2
Benign
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 11 | 0 | 11 |
Likely Pathogenic | 0 | 0 | 0 | 0 | 0 |
VUS | 0 | 28 | 1 | 0 | 29 |
Likely Benign | 0 | 0 | 0 | 0 | 0 |
Benign | 0 | 0 | 0 | 2 | 2 |
| Total | 0 | 28 | 12 | 2 | 42 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
GNA13 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype Relationships
1 OMIM entry
GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-13; GNA13
MIM #604406 · *
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma.
Shen R et al.·Signal Transduct Target Ther
2023
Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma.
Thomas N et al.·Blood
2023
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
[Retracted] miRNA-30d serves a critical function in colorectal cancer initiation, progression and invasion via directly targeting the GNA13 gene.
Muhammad S et al.·Exp Ther Med
2026Open Access
GNA13 promotes brain metastasis of non-small cell lung cancer and EMT through the WNT/β catenin signaling pathway.
Wu JQ et al.·Front Cell Dev Biol
2025Open Access
Zinc finger DHHC-type palmitoyltransferase 13-mediated S-palmitoylation of GNA13 from Sertoli cell-derived extracellular vesicles inhibits autophagy in spermatogonial stem cells.
Cao H et al.·Cell Commun Signal
2025Open Access
Top 5 resultsSearch Europe PMC ↗
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Modified Electroconvulsive Therapy Normalizes Plasma GNA13 Following Schizophrenic Relapse.
Zhang H et al.·J ECT
2024
GNA13 inhibits glioblastoma metastasis via the ERKs/FOXO3 signaling pathway.
Yi Q et al.·Cell Signal
2023
Overexpression of GNA13 correlates with poor prognosis in esophageal squamous cell carcinoma after esophagectomy.
Pan Z et al.·Int J Biol Markers
2022
Identification of potentially functional modules and diagnostic genes related to amyotrophic lateral sclerosis based on the WGCNA and LASSO algorithms
Daneshafrooz N et al.·Sci Rep
2022Functional
Nasal Delivery of Engineered Exosomes via a Thermo-Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair
Wang Y et al.·Adv Sci (Weinh)
2025
Genome-Wide Association Studies for Growth Curves in Meat Rabbits Through the Single-Step Nonlinear Mixed Model
Liao Y et al.·Front Genet
2021Functional
GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner
Xia Z et al.·Cell Death Dis
2021
Overexpressed GNA13 induces temozolomide sensitization via down-regulating MGMT and p-RELA in glioma.
Liu Y et al.·Am J Transl Res
2021
Top 8 full-text resultsSearch PubTator3 ↗
External Resources
Links to major genomics databases and tools