GLYATL1B

Chr 11

glycine-N-acyltransferase like 1B

Also known as: GLYATL1P3

NCBI Gene: 100287520 ENSG00000255151 UniProt: A0A0U1RQE8

Predicted to enable L-glutamine N-acyltransferase activity. Predicted to be involved in L-glutamine metabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Jun 2026]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in GLYATL1B?

gnomAD v4 · ~327k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 83

234 rare PASS variants

Rare truncating (LoF)

1 in 980

33 rare PASS variants

Rare synonymous (reference)

1 in 180

94 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for GLYATL1B. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~206k	1 in 97	1 in 1,100
South Asian	~29k	1 in 110	≈ 1 in 18,000
European (Finnish)	~25k	1 in 250	1 in 600
African / African American	~21k	1 in 48	1 in 1,700
Admixed American	~19k	1 in 75	≈ 1 in 3,900
East Asian	~17k	1 in 98	1 in 410
Remaining (unassigned)	~17k	1 in 73	1 in 610
Ashkenazi Jewish	~9,194	1 in 350	≈ 1 in 5,500
Middle Eastern	~1,955	1 in 79	≈ 1 in 730

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 0 of 5 coding exons well covered in gnomAD exomes; exons 1, 2, 3, 4, 5 poorly covered. Genomes: all 5.? see exons ↓