GLYATL1

Chr 11

glycine-N-acyltransferase like 1

Also known as: GATF-C, GNAT

NCBI Gene: 92292 ENSG00000166840 UniProt: Q969I3 OMIM: 614761

Enables L-glutamine N-acyltransferase activity. Involved in L-glutamine metabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Jun 2026]

OMIM Research

Enables L-glutamine N-acyltransferase activity. Involved in L-glutamine metabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.92

LOEUF

—

Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

0.92LOEUF

pLI 0.003

Z-score 1.78

OE 0.46 (0.25–0.92)

Tolerant

Typical tolerance to LoF variation

Missense Constraint?

-0.62Z-score

OE missense 1.13 (1.01–1.26)

209 obs / 185.3 exp

Tolerant

Tolerant to missense variation

Observed / Expected Ratios?

LoF OE?0.46 (0.25–0.92)

0≤0.351.4

Missense OE?1.13 (1.01–1.26)

0≤0.61.4

Synonymous OE?1.14

0≤1.21.6

LoF obs/exp: 6 / 12.9Missense obs/exp: 209 / 185.3Syn Z: -0.90

Background carrier burden — how many people carry a rare variant somewhere in GLYATL1?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 99

471 rare PASS variants

Rare truncating (LoF)

1 in 490

95 rare PASS variants

Rare synonymous (reference)

1 in 190

185 rare PASS variants

Rare missense and truncating variants are carried at similar rates in GLYATL1; this gene does not show strong loss-of-function constraint by this measure. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 120	1 in 410
South Asian	~43k	1 in 88	1 in 2,500
Remaining (unassigned)	~30k	1 in 85	1 in 740
European (Finnish)	~27k	1 in 350	≈ 1 in 5,300
Admixed American	~22k	1 in 130	1 in 1,700
African / African American	~21k	1 in 83	1 in 580
East Asian	~20k	1 in 130	1 in 950
Ashkenazi Jewish	~13k	1 in 480	1 in 1,300
Middle Eastern	~2,884	1 in 210	1 in 580

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 5 coding exons well covered in gnomAD exomes and genomes.? see exons ↓