GLP1R
Chr 6glucagon like peptide 1 receptor
Also known as: GLP-1, GLP-1-R, GLP-1R
This gene encodes a 7-transmembrane receptor for glucagon-like peptide 1 (GLP-1), which stimulates glucose-dependent insulin secretion. The receptor, located on the cell surface, is internalized upon ligand binding and triggers signaling pathways that regulate insulin release, appetite, gastric emptying, and energy balance. It also has neuroprotective and cardiovascular effects. Polymorphisms in this gene are linked to type 2 diabetes risk, and the receptor is a key drug target for diabetes, obesity, and stroke therapies. [provided by RefSeq, Mar 2026]
Some data sources returned errors (2)
gnomad: Error: gnomAD API error: 502
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
GLP1R · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Expression of GLP1 Receptor on Peripheral Blood Mononuclear Cells in Advanced Peripheral Artery Disease: Paving the Way for GLP1R Agonists Treatment in Chronic Limb Threatening Ischemia
NOT YET RECRUITINGMonitoring and Managing Glucose Levels in People With Pancreatic Cancer
RECRUITINGTirzepatide Impact Assessment Study
RECRUITINGEllacor® Micro-Coring Technology® in Fitzpatrick Skin Types I-VI, Including Patients Receiving Glucagon-Like Peptide-1 Receptor Agonists
RECRUITINGThe MICRON Study - A Steno 1 Substudy
RECRUITINGRole of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment
RECRUITINGHormonal and Microbiota Modulation After Endoscopic Sleeve Gastroplasty
NOT YET RECRUITINGTransformative Research in Diabetic Nephropathy 2.0
RECRUITINGGlucagon-Like Peptide-1 Receptor Agonist in ADPKD
RECRUITINGPathogenesis of Chronic Kidney Disease Associated With Metabolic Dysfunction- Associated Fatty Liver Disease (MAFLD) and Treatment Response of Oral Semaglutide.
NOT YET RECRUITINGEvaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer
NOT YET RECRUITINGPharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
RECRUITINGExternal Resources
Links to major genomics databases and tools