GLI4

Chr 8

GLI family zinc finger 4

Also known as: HKR4, ZNF928

NCBI Gene: 2738 ENSG00000250571 UniProt: P10075 OMIM: 165280

The protein is predicted to function as a DNA-binding transcription factor that regulates gene transcription by binding to specific DNA sequences and interacting with RNA polymerase II. This gene is not well-constrained against loss-of-function variants (pLI = 0.002, LOEUF = 0.98), suggesting it may tolerate such variants in the general population. Currently, no established human diseases or clear inheritance patterns have been definitively associated with GLI4 mutations in the literature.

OMIM ResearchSummary from RefSeq

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.98

LOEUF

Multiple*

Mechanism· predicted