GLCCI1

Chr 7

glucocorticoid induced 1

Also known as: FAM117C, GCTR, GIG18, TSSN1

NCBI Gene: 113263 ENSG00000106415 UniProt: Q86VQ1

This gene encodes a protein of unknown function that is induced by glucocorticoids and may serve as an early marker for glucocorticoid-induced apoptosis. Polymorphisms in GLCCI1 are associated with decreased response to inhaled glucocorticoid therapy in asthmatic patients. The gene is highly constrained against loss-of-function variants (LOEUF 0.575), suggesting an important biological role despite its unknown function.

ResearchSummary from RefSeq, OMIM

This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.57

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

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