GHRLOS

This antisense gene regulates the ghrelin/obestatin prepropeptide gene through non-coding regulatory RNAs produced by alternative splicing. Mutations cause autosomal dominant Silver-Russell syndrome, a growth disorder characterized by severe intrauterine and postnatal growth restriction, relative macrocephaly, and distinctive facial features with onset in infancy. The gene shows high constraint against loss-of-function variants, indicating its critical regulatory role in growth and development.