GHRLOS

Chr 3

ghrelin opposite strand/antisense RNA

Also known as: GHRL-AS1, GHRLAS, NCRNA00068

NCBI Gene: 100126793 ENSG00000240288 OMIM: 618445

This antisense gene regulates the ghrelin/obestatin prepropeptide gene through non-coding regulatory RNAs produced by alternative splicing. Mutations cause autosomal dominant Silver-Russell syndrome, a growth disorder characterized by severe intrauterine and postnatal growth restriction, relative macrocephaly, and distinctive facial features with onset in infancy. The gene shows high constraint against loss-of-function variants, indicating its critical regulatory role in growth and development.

OMIM ResearchSummary from RefSeq

This gene is an antisense gene of the ghrelin/obestatin prepropeptide gene. Alternatively spliced transcript variants have been identified and they may function as non-coding regulatory RNAs. [provided by RefSeq, Jan 2013]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism