GHET1

Chr 7

gastric carcinoma proliferation enhancing transcript 1

Also known as: GHET-1, lncRNA-GHET1

NCBI Gene: 102723099ENSG00000281189

This gene encodes an unspliced long non-coding RNA that has been suggested to promote the proliferation of gastric carcinoma cells and bladder cancer cells. [provided by RefSeq, Dec 2014]

29
ClinVar variants
29
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— GHET1
📋
ClinVar Variants
29 Pathogenic / Likely Pathogenic of 29 total submissions
Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

29 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic26
Likely Pathogenic3
26
Pathogenic
3
Likely Pathogenic

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————26
Likely Pathogenic
————3
VUS
————0
Likely Benign
————0
Benign
————0
Total—29

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

GHET1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers.
Jiang YF et al.·J Cell Mol Med
2019Meta-analysis
Prognostic and Clinicopathological Significance of Long Noncoding RNA GHET1 in Human Solid Tumors: a Meta-Analysis.
Zeng L et al.·Clin Lab
2020Meta-analysis
Expression and clinical significance of long-non-coding RNA GHET1 in pancreatic cancer.
Zhou HY et al.·Eur Rev Med Pharmacol Sci
2017
Prognostic significance of LncRNA GHET1 expression in various cancers: a systematic review and meta-analysis.
Ye J et al.·Biosci Rep
2019Meta-analysis
Long noncoding RNA GHET1 in human cancer.
Li J et al.·Clin Chim Acta
2019Review
Clinicopathological Significance of Long Non-Coding RNA GHET1 in Human Cancers: A Meta-Analysis.
Poursheikhani A et al.·Curr Pharm Biotechnol
2020Meta-analysis
lncRNA GHET1 regulates extravillous trophoblastic phenotype via EZH2/LSD1-mediated MT2A epigenetic suppression in pre-eclampsia.
Wan P et al.·Mol Reprod Dev
2023
The Value of lncRNA GHET1 as a Prognostic Factor for Survival of Chinese Cancer Outcome: A Meta-Analysis.
Song J et al.·Dis Markers
2019Meta-analysis
LncRNA GHET1 predicts poor prognosis in hepatocellular carcinoma and promotes cell proliferation by silencing KLF2.
Jin L et al.·J Cell Physiol
2018
Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo.
Yang W et al.·Cancer Biomark
2018
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools