GFRAL

Chr 6

GDNF family receptor alpha like

Also known as: C6orf144, GRAL, UNQ9356, bA360D14.1

NCBI Gene: 389400ENSG00000187871UniProt: Q6UXV0

Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in GDF15-GFRAL signaling pathway; positive regulation of MAPK cascade; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
62
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.26
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.26LOEUF
pLI 0.000
Z-score 0.70
OE 0.83 (0.56–1.26)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.63Z-score
OE missense 1.12 (1.01–1.25)
230 obs / 204.6 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.83 (0.56–1.26)
0≤0.351.4
Missense OE?1.12 (1.01–1.25)
0≤0.61.4
Synonymous OE?0.99
0≤1.21.6
LoF obs/exp: 16 / 19.3Missense obs/exp: 230 / 204.6Syn Z: 0.05

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

GFRAL · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients