GEFSP7

Chr 2AD

Generalized epilepsy with febrile seizures plus, type 7

Also known as: FEB3B

The GEFSP7 gene encodes a protein involved in neuronal excitability regulation. Mutations cause generalized epilepsy with febrile seizures plus, type 7, characterized by febrile seizures in early childhood that may progress to afebrile generalized seizures. This condition follows an autosomal dominant inheritance pattern.

Summary from OMIM
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Primary Disease Associations & Inheritance

Generalized epilepsy with febrile seizures plus, type 7MIM #613863
AD
0
Active trials
0
Pubs (1 yr)
0
P/LP submissions
P/LP missense
LOEUF
Mechanism
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/GEFSP7?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

GEFSP7 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
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Top 3 full-text resultsSearch PubTator3 ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found