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GD3

Chr XAR

Graves disease, susceptibility to, X-linked

Also known as: GD3

Glucocerebrosidase breaks down the lipid glucocerebroside within lysosomes. Mutations cause Gaucher disease type III, a neuronopathic form with chronic neurological involvement including seizures, developmental delay, and progressive neurodegeneration typically beginning in childhood. Inheritance is autosomal recessive.

GeneReviewsOMIMResearchSummary from OMIM
AR1 OMIM phenotype
Clinical SummaryGD3
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Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available
📖
GeneReview available — GD3
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/GD3?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

GD3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold
Clinical Literature
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