GALR1

Chr 18

galanin receptor 1

Also known as: GALNR, GALNR1

NCBI Gene: 2587 ENSG00000166573 UniProt: P47211

The GALR1 protein is a G-protein-coupled receptor for the neuropeptide galanin that inhibits adenylyl cyclase activity and is widely expressed in the brain, spinal cord, and peripheral tissues including small intestine and heart. Currently, no human diseases have been definitively associated with GALR1 mutations in the medical literature. The gene shows low constraint to loss-of-function variation (pLI = 0.0005, LOEUF = 1.347), suggesting that complete loss of function may be well tolerated.

ResearchSummary from RefSeq, UniProt

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.35

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)