FOXM1

Chr 12

forkhead box M1

Also known as: FKHL16, FOXM1A, FOXM1B, FOXM1C, HFH-11, HFH11, HNF-3, INS-1

NCBI Gene: 2305ENSG00000111206UniProt: Q08050OMIM: 602341

The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

OMIMResearchGenerating clinical summary…
3
Active trials
430
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.59
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.59LOEUF
pLI 0.001
Z-score 3.30
OE 0.36 (0.22–0.59)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
0.71Z-score
OE missense 0.91 (0.83–0.98)
407 obs / 449.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.36 (0.22–0.59)
0≤0.351.4
Missense OE?0.91 (0.83–0.98)
0≤0.61.4
Synonymous OE?1.04
0≤1.21.6
LoF obs/exp: 11 / 30.8Missense obs/exp: 407 / 449.1Syn Z: -0.39

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FOXM1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients