FOXM1
Chr 12forkhead box M1
Also known as: FKHL16, FOXM1A, FOXM1B, FOXM1C, HFH-11, HFH11, HNF-3, INS-1
FOXM1 encodes a transcription factor that regulates expression of cell cycle genes essential for DNA replication and mitosis, and participates in DNA damage checkpoint responses. The gene is highly constrained against loss-of-function variants (LOEUF 0.59), but specific disease associations with FOXM1 mutations have not been established in the provided data. Additional clinical and genetic evidence would be needed to determine disease phenotypes and inheritance patterns associated with this gene.
Some data sources returned errors (1)
pubtator: TimeoutError: The operation was aborted due to timeout
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
FOXM1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Transformative Research in Diabetic Nephropathy 2.0
RECRUITINGBILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention
NOT YET RECRUITINGRANKL Inhibition and Mammographic Breast Density
ACTIVE NOT RECRUITINGExternal Resources
Links to major genomics databases and tools