FOXD4L4
Chr 9forkhead box D4 like 4
Also known as: FOXD4L2, FOXD4b, bA460E7.2
The protein is predicted to function as a DNA-binding transcription factor that regulates gene expression by RNA polymerase II and is involved in cell differentiation and anatomical structure development. Currently, no established human diseases have been definitively associated with mutations in this gene. The inheritance pattern for any potential disorders remains to be determined as clinical associations are still being investigated.
Population Genetics & Constraint
Constraint data not available from gnomAD.
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
FOXD4L4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools